Article
Nonsteroidal anti-inflammatory drug-activated gene-1 over expression in transgenic mice suppresses intestinal neoplasia.
Gastroenterology - 1 Nov 2006
Baek Seung Joon, Okazaki Ryuji, Lee Seong-Ho, Martinez Jeanelle, Kim Jong-Sik, Yamaguchi Kiyoshi, Mishina Yuji, Martin David W, Shoieb Ahmed, McEntee Michael F, Eling Thomas E
Abstract excerpt
BACKGROUND & AIMS: The nonsteroidal anti-inflammatory drug-activated gene (NAG-1) was identified as a proapoptotic, antitumorigenic protein in vitro, induced by many antitumorigenic and chemopreventive drugs including cyclooxygenase inhibitors. However, its antitumorigenic activity has not been elucidated in vivo. METHODS: Transgenic mice were generated that ubiquitously overexpress human NAG-1 under the control...
Topics
- Animals
- Cytokines
- Female
- Genes, APC
- Genes, Tumor Suppressor
- Growth Differentiation Factor 15
- Humans
- Intestinal Neoplasms
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Mutation