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Article

Nonsteroidal anti-inflammatory drug-activated gene-1 over expression in transgenic mice suppresses intestinal neoplasia.

Gastroenterology - 1 Nov 2006

Baek Seung Joon, Okazaki Ryuji, Lee Seong-Ho, Martinez Jeanelle, Kim Jong-Sik, Yamaguchi Kiyoshi, Mishina Yuji, Martin David W, Shoieb Ahmed, McEntee Michael F, Eling Thomas E

Abstract excerpt

BACKGROUND & AIMS: The nonsteroidal anti-inflammatory drug-activated gene (NAG-1) was identified as a proapoptotic, antitumorigenic protein in vitro, induced by many antitumorigenic and chemopreventive drugs including cyclooxygenase inhibitors. However, its antitumorigenic activity has not been elucidated in vivo. METHODS: Transgenic mice were generated that ubiquitously overexpress human NAG-1 under the control...

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PMID: 17101328
DOI: 10.1053/j.gastro.2006.09.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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