Article
The correlation of hepatitis B virus pre-S mutation with cellular oxidative DNA damage in hepatocellular carcinoma.
Hepato-gastroenterology - 1 Jan 2000
Gwak Geum-Youn, Lee Dong Ho, Moon Tae Gun, Choi Moon Seok, Lee Joon Hyeok, Koh Kwang Cheol, Paik Seung Woon, Park Cheol Keun, Joh Jae-Won, Yoo Byung Chul
Abstract excerpt
BACKGROUND/AIMS: Recent research has proposed a role for HBV pre-S mutation in the development of HCC. Although the mechanism is not clear, pre-S mutant-induced endoplasmic reticulum (ER) stress and oxidative DNA damage may participate in this process. Therefore, we investigated the correlation of HBV pre-S mutation with ER stress and cellular oxidative DNA damage in HBV-related HCC patients. METHODOLOGY: Thirty...
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