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Article

The role of von Hippel-Lindau tumor suppressor protein and hypoxia in renal clear cell carcinoma.

American journal of physiology. Renal physiology - 1 Jul 2004

Sufan Roxana I, Jewett Michael A S, Ohh Michael

Abstract excerpt

The majority of kidney cancers are caused by the mutation of the von Hippel-Lindau (VHL) tumor suppressor gene. VHL protein (pVHL) is part of an E3 ubiquitin ligase complex called VEC that is composed of elongin B, elongin C, cullin 2, NEDD8, and Rbx1. VEC targets a hypoxia-inducible factor (HIF) transcription factor for ubiquitin-mediated destruction selectively in the presence of oxygen. In the absence of...

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Source

Identifiers

PMID: 15180922
DOI: 10.1152/ajprenal.00424.2003

Genes

VHL
NEDD8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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