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Article

The VHL tumor suppressor and HIF: insights from genetic studies in mice.

Cell death and differentiation - 1 Apr 2008

Kapitsinou P P, Haase V H

Abstract excerpt

The von Hippel-Lindau tumor suppressor gene product, pVHL, functions as the substrate recognition component of an E3-ubiquitin ligase, which targets the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF) for rapid proteasomal degradation under normoxic conditions and as such plays a central role in molecular oxygen sensing. Mutations in pVHL can be found in familial and sporadic clear cell...

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Source

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Identifiers

PMID: 18219317
DOI: 10.1038/sj.cdd.4402313
PMCID: PMC3799983

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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