Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Von Hippel-Lindau Tumor Suppressor Gene and Kidney Cancer

15 Sept 2004

Abstract excerpt

The von Hippel-Lindau tumor suppressor gene (VHL), which resides on chromosome 3p25, is mutated or silenced in >50% of sporadic clear cell renal cell carcinomas. Germ-line VHL mutations give rise to VHL disease, which is characterized by an increased risk of blood vessel tumors (hemangioblastomas) and renal cell carcinomas. In this setting, VHL inactivation gives rise to premalignant renal cysts. Additional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenal and Paraganglionic Tumors
Share to Cancer, Hypoxia, and Metabolism
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15448019
DOI: 10.1158/1078-0432.ccr-sup-040025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Von Hippel-Lindau Tumor Suppressor Gene and Kidney CancerPMID 15448019Read ↗

The von Hippel-Lindau tumor suppressor gene.Semantic proximity Read ↗

von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.Semantic proximity Read ↗

Role of VHL gene mutation in human renal cell carcinoma.Semantic proximity Read ↗

The VHL tumor suppressor and HIF: insights from genetic studies in mice.Semantic proximity Read ↗

Hypoxia-inducible factor linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations.Semantic proximity Read ↗

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein.Semantic proximity Read ↗

[Von-Hippel-Lindau (VHL) protein function by initiation and progression of renal cancer].Semantic proximity Read ↗

The von Hippel-Lindau tumor suppressor protein: roles in cancer and oxygen sensing.Semantic proximity Read ↗

The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma.Semantic proximity Read ↗

Role of the<i>VHL</i>(von Hippel–Lindau) gene in renal cancer: a multifunctional tumour suppressorSemantic proximity Read ↗

Role of VHL gene mutation in human cancer.Semantic proximity Read ↗

Von Hippel‐Lindau diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.