Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Von-Hippel-Lindau (VHL) protein function by initiation and progression of renal cancer].

Der Pathologe - 1 Nov 2008

Moch H

Abstract excerpt

Germ line inactivation of the von-Hippel-Lindau (VHL) tumor suppressor gene causes von Hippel-Lindau hereditary cancer syndrome, and somatic mutations of this gene have been linked to the development of sporadic hemangioblastomas and clear cell renal carcinomas. The protein encoded by VHL, pVHL, has no known enzymatic activities but interacts with various partner proteins. In this review, various pVHL functions...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Carcinoma, Renal Cell
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

Share to Gene Expression Regulation, Neoplastic

Share to Kidney Neoplasms

Share to von Hippel-Lindau Disease

Share to Von Hippel-Lindau Tumor Suppressor Protein

Source

Identifiers

PMID: 18751708
DOI: 10.1007/s00292-008-1034-y

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Von-Hippel-Lindau (VHL) protein function by initiation and progression of renal cancer].PMID 18751708Read ↗

Recent advances in etiology and treatment of von Hippel-Lindau Disease (VHLD).Semantic proximity Read ↗

The Von Hippel-Lindau Tumor Suppressor Gene and Kidney CancerSemantic proximity Read ↗

von Hippel-Lindau disease: recent advances and therapeutic perspectives.Semantic proximity Read ↗

The von Hippel-Lindau tumor suppressor gene.Semantic proximity Read ↗

Two sides to every story: the HIF-dependent and HIF-independent functions of pVHLSemantic proximity Read ↗

The von Hippel-Lindau tumor suppressor protein: roles in cancer and oxygen sensing.Semantic proximity Read ↗

Genetics, Pathophysiology, and Current Challenges in Von Hippel-Lindau Disease TherapeuticsSemantic proximity Read ↗

VHL, the story of a tumour suppressor gene.Semantic proximity Read ↗

The VHL tumor suppressor and HIF: insights from genetic studies in mice.Semantic proximity Read ↗

Role of the<i>VHL</i>(von Hippel–Lindau) gene in renal cancer: a multifunctional tumour suppressorSemantic proximity Read ↗

von Hippel-Lindau Disease: an UpdateSemantic proximity Read ↗

Von Hippel–Lindau Disease: Molecular Pathological Basis, Clinical Criteria, Genetic Testing, Clinical Features of Tumors and TreatmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.