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Article

VHL, the story of a tumour suppressor gene.

Nature reviews. Cancer - 1 Jan 2015

Gossage Lucy, Eisen Tim, Maher Eamonn R

Abstract excerpt

Since the Von Hippel-Lindau (VHL) disease tumour suppressor gene VHL was identified in 1993 as the genetic basis for a rare disorder, it has proved to be of wide medical and scientific interest. VHL tumour suppressor protein (pVHL) plays a key part in cellular oxygen sensing by targeting hypoxia-inducible factors for ubiquitylation and proteasomal degradation. Early inactivation of VHL is commonly seen in...

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Source

Identifiers

PMID: 25533676
DOI: 10.1038/nrc3844

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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