Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypoxia-inducible factor linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations.

Molecular and cellular biology - 1 Aug 2007

Li Lianjie, Zhang Liang, Zhang Xiaoping, Yan Qin, Minamishima Yoji Andrew, Olumi Aria F, Mao Mao, Bartz Steven, Kaelin William G

Abstract excerpt

Clear cell carcinoma of the kidney is a major cause of mortality in patients with von Hippel-Lindau (VHL) disease, which is caused by germ line mutations that inactivate the VHL tumor suppressor gene. Biallelic VHL inactivation, due to mutations or hypermethylation, is also common in sporadic clear cell renal carcinomas. The VHL gene product, pVHL, is part of a ubiquitin ligase complex that targets the alpha...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Transcription Factors
Share to Carcinoma, Renal Cell

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Cycle

Share to Down-Regulation

Share to Kidney Neoplasms

Share to Mutant Proteins

Share to Spheroids, Cellular

Share to Von Hippel-Lindau Tumor Suppressor Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 17526729
DOI: 10.1128/MCB.00282-07
PMCID: PMC1952077

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypoxia-inducible factor linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations.PMID 17526729Read ↗

von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.Semantic proximity Read ↗

The Von Hippel-Lindau Tumor Suppressor Gene and Kidney CancerSemantic proximity Read ↗

The von Hippel-Lindau tumor suppressor gene.Semantic proximity Read ↗

The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma.Semantic proximity Read ↗

Differences in regulation of tight junctions and cell morphology between VHL mutations from disease subtypes.Semantic proximity Read ↗

Clinical and functional properties of novel VHL mutation (X214L) consistent with Type 2A phenotype and low risk of renal cell carcinoma.Semantic proximity Read ↗

Treatment of kidney cancerSemantic proximity Read ↗

VHL, the story of a tumour suppressor gene.Semantic proximity Read ↗

A clearer view of the molecular complexity of clear cell renal cell carcinoma.Semantic proximity Read ↗

The role of von Hippel-Lindau tumor suppressor protein and hypoxia in renal clear cell carcinoma.Semantic proximity Read ↗

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.Semantic proximity Read ↗

VHLinactivation in renal cell carcinoma: implications for diagnosis, prognosis and treatmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.