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Article

Role of the<i>VHL</i>(von Hippel–Lindau) gene in renal cancer: a multifunctional tumour suppressor

21 May 2008

Abstract excerpt

The VHL (von Hippel-Lindau) tumour-suppressor gene is inactivated in VHL disease and in sporadic cases of CCRCC [clear-cell RCC (renal cell carcinoma)]. pVHL (VHL protein) functions as part of an E3 ubiquitin ligase complex that targets proteins for proteasomal degradation. The best-characterized substrate is HIF-alpha (hypoxia-inducible factor-alpha). Loss of pVHL and subsequent up-regulation of HIF target genes...

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Identifiers

PMID: 18481984
DOI: 10.1042/bst0360472

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