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Article

Impaired dense core vesicle maturation in Caenorhabditis elegans mutants lacking Rab2.

The Journal of cell biology - 21 Sept 2009

Edwards Stacey L, Charlie Nicole K, Richmond Janet E, Hegermann Jan, Eimer Stefan, Miller Kenneth G

Abstract excerpt

Despite a key role for dense core vesicles (DCVs) in neuronal function, there are major gaps in our understanding of DCV biogenesis. A genetic screen for Caenorhabditis elegans mutants with behavioral defects consistent with impaired DCV function yielded five mutations in UNC-108 (Rab2). A genetic analysis showed that unc-108 mutations impair a DCV function unrelated to neuropeptide release that, together with...

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Identifiers

PMID: 19797080
DOI: 10.1083/jcb.200902095
PMCID: PMC2753164

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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