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Article

Loss of the transcriptional repressor PAG-3/Gfi-1 results in enhanced neurosecretion that is dependent on the dense-core vesicle membrane protein IDA-1/IA-2.

PLoS genetics - 1 Apr 2009

Cai Tao, Hirai Hiroki, Fukushige Tetsunari, Yu Ping, Zhang Guofeng, Notkins Abner L, Krause Michael

Abstract excerpt

It is generally accepted that neuroendocrine cells regulate dense core vesicle (DCV) biogenesis and cargo packaging in response to secretory demands, although the molecular mechanisms of this process are poorly understood. One factor that has previously been implicated in DCV regulation is IA-2,...

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Identifiers

PMID: 19343207
DOI: 10.1371/journal.pgen.1000447
PMCID: PMC2657203

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19343207-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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