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Article

Cyclin-dependent kinase 5 regulates the polarized trafficking of neuropeptide-containing dense-core vesicles in Caenorhabditis elegans motor neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 13 Jun 2012

Goodwin Patricia R, Sasaki Jennifer M, Juo Peter

Abstract excerpt

The polarized trafficking of axonal and dendritic proteins is essential for the structure and function of neurons. Cyclin-dependent kinase 5 (CDK-5) and its activator CDKA-1/p35 regulate diverse aspects of nervous system development and function. Here, we show that CDK-5 and CDKA-1/p35 are required for the polarized distribution of neuropeptide-containing dense-core vesicles (DCVs) in Caenorhabditis elegans...

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Source

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Identifiers

PMID: 22699897
DOI: 10.1523/JNEUROSCI.0251-12.2012
PMCID: PMC3392131

Genes

INS
KIF1A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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