Article
Analysis of association at single nucleotide polymorphisms in the APOE region.
Genomics - 1 Jan 2000
Martin E R, Gilbert J R, Lai E H, Riley J, Rogala A R, Slotterbeck B D, Sipe C A, Grubber J M, Warren L L, Conneally P M, Saunders A M, Schmechel D E, Purvis I, Pericak-Vance M A, Roses A D, Vance J M
Abstract excerpt
The discussion of the prospects of using a dense map of single nucleotide polymorphisms (SNPs) to identify disease genes with association analysis has been extensive. However, there is little empiric evidence to support this strategy. To begin to examine the practical issues surrounding this methodology, we identified 10 SNPs in the region immediately surrounding the apolipoprotein E locus (APOE), an established...
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