Article
Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese.
Genomics - 1 May 2009
Takei Norihiro, Miyashita Akinori, Tsukie Tamao, Arai Hiroyuki, Asada Takashi, Imagawa Masaki, Shoji Mikio, Higuchi Susumu, Urakami Katsuya, Kimura Hideo, Kakita Akiyoshi, Takahashi Hitoshi, Tsuji Shoji, Kanazawa Ichiro, Ihara Yasuo, Odani Shoji, Kuwano Ryozo
Abstract excerpt
The epsilon4 allele of APOE is a well-characterized genetic risk factor for late-onset Alzheimer disease (LOAD). Nevertheless, using high-density single nucleotide polymorphisms (SNPs), there have only been a few studies involving genetic association and linkage disequilibrium (LD) analyses of in and around the APOE. Here, we report fine mapping of a genomic region (about 200 kb) including the APOE in Japanese...
Topics
- Age of Onset
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Apolipoprotein C-I
- Apolipoproteins E
- Asian People
- Cell Adhesion Molecules
- Chromosome Mapping
- Female