Article
Association between genetic variation in the gene for death-associated protein-3 (DAP3) and adult asthma.
Journal of human genetics - 1 Jan 2004
Hirota Tomomitsu, Obara Kazuhiko, Matsuda Akira, Akahoshi Mitsuteru, Nakashima Kazuko, Hasegawa Koichi, Takahashi Naomi, Shimizu Makiko, Sekiguchi Hiroshi, Kokubo Miki, Doi Satoru, Fujiwara Hiroshi, Miyatake Akihiko, Fujita Kimie, Enomoto Tadao, Kishi Fumio, Suzuki Yoichi, Saito Hirohisa, Nakamura Yusuke, Shirakawa Taro, Tamari Mayumi
Abstract excerpt
Lung epithelium plays a central role in modulation of the lung inflammatory response, and lung repair and airway epithelial cells are targets in asthma and viral infection. Activated T lymphocytes release cytokines such as interferon-gamma (IFN-gamma) that induce apoptosis, or programmed cell death, of damaged epithelial cells. Death-associated protein-3 (DAP3) is involved in mediating IFN-gamma-induced cell...
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