Article
BIRC3 single nucleotide polymorphism associate with asthma susceptibility and the abundance of eosinophils and neutrophils.
The Journal of asthma : official journal of the Association for the Care of Asthma - 1 Mar 2017
Roscioli Eugene, Hamon Rhys, Ruffin Richard E, Grant Janet, Hodge Sandra, Zalewski Peter, Lester Susan
Abstract excerpt
BACKGROUND AND OBJECTIVE: Aberrant apoptosis is a disease susceptibility mechanism relevant for asthma, whereby fragility of the airway epithelium and enhanced survival of inflammatory cells, contributes to its pathogenesis and prolongation. Cellular Inhibitor of Apoptosis Proteins (cIAP) suppress apoptosis, and participate in the immune response. In this study, single nucleotide polymorphisms (SNP) in the BIRC2...
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