Article
Association study of the C3 gene with adult and childhood asthma.
Journal of human genetics - 1 Jan 2008
Inoue Hiroki, Mashimo Yoichi, Funamizu Makiko, Shimojo Naoki, Hasegawa Koichi, Hirota Tomomitsu, Doi Satoru, Kameda Makoto, Miyatake Akihiko, Kohno Yoichi, Okamoto Yoshitaka, Tamari Mayumi, Hata Akira, Suzuki Yoichi
Abstract excerpt
Bronchial asthma (BA) is a multifactorial disorder, the development of which is affected by both environmental and genetic factors. The complement system plays an important role in immunological response against invading microorganisms. It has been shown that complement-C3-deficient mice have reduced inflammation of asthmatic airways. Previously, we reported the association of four single nuclear proteins (SNPs)...
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