Article
Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor.
Cell - 6 Oct 1995
Wu H, Liu X, Jaenisch R, Lodish H F
Abstract excerpt
Erythropoietin (EPO) is the principal growth factor regulating the production of circulating erythrocytes. We introduced null mutations into both Epo and the EPO receptor (EpoR) gene. Both heterozygotes appeared normal. Homozygous animals exhibited reduced primitive erythropoiesis and died around...
Topics
- Animals
- Cell Lineage
- Erythroid Precursor Cells
- Erythropoiesis
- Erythropoietin
- Female
- Gene Targeting
- Genes, Lethal
- Genotype
- Hematopoiesis, Extramedullary
- Hematopoietic Stem Cells
- Humans
- Liver
- Maternal-Fetal Exchange
- Mice
- Phenotype
- Pregnancy
- Receptors, Erythropoietin