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Article

Erythropoietin receptor signaling regulates both erythropoiesis and megakaryopoiesis in vivo.

Blood cells, molecules & diseases - 15 Jan 2010

Huang Xiaosong, Pierce L Jeanne, Chen George L, Chang Ko-Tung, Spangrude Gerald J, Prchal Josef T

Abstract excerpt

Transgenic expression of a gain-of-function truncated mouse erythropoietin receptor gene (EpoR) leads to expansion of the HSC pool in response to human erythropoietin (Epo). We have re-examined this observation using a knock-in mouse model, wherein the mouse EpoR gene was replaced in its proper genetic locus by a single copy of either a wild-type human or a polycythemia-inducing truncated human EPOR gene. Bone...

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Identifiers

PMID: 19836979
DOI: 10.1016/j.bcmd.2009.09.007
PMCID: PMC2818228

Genes

EPOR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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