Article
Combined action of c-kit and erythropoietin on erythroid progenitor cells.
Development (Cambridge, England) - 1 Jan 1992
Ohneda O, Yanai N, Obinata M
Abstract excerpt
Mutations at the murine dominant-white spotting locus (W) (c-kit) affect various aspects of hematopoiesis. We have made antibodies against c-Kit with the synthetic peptides deduced from the murine c-kit gene and examined the role of c-Kit in erythropoiesis. The antibody inhibited the stromal cell-dependent large colony formation of the erythroid progenitors. In the culture of erythropoietin-responsive erythroid...
Topics
- Animals
- Antibodies, Monoclonal
- Cell Differentiation
- Cell Division
- Erythroid Precursor Cells
- Erythropoiesis
- Erythropoietin
- Gene Expression Regulation
- Genotype
- Mice
- Mutation
- Proto-Oncogene Proteins