Article
Prosomatostatin is proteolytically processed at the amino terminal segment by subtilase SKI-1.
Regulatory peptides - 15 Aug 2004
Mouchantaf R, Watt H L, Sulea T, Seidah N G, Alturaihi H, Patel Y C, Kumar U
Abstract excerpt
Processing of prohormones to generate active products typically occurs at basic residues via cleavage by proprotein convertases. A less common type of cleavage is mediated at hydrophobic (L, V, F, N) or small amino acid (A, T, S) residues. Efforts to identify the proteinases responsible for processing precursors at their hydrophobic amino acids has led to the recent cloning of a new type-1 membrane-bound...
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