Article
Furin is the major proprotein convertase required for KISS1-to-Kisspeptin processing.
PloS one - 1 Jan 2014
Harihar Sitaram, Pounds Keke M, Iwakuma Tomoo, Seidah Nabil G, Welch Danny R
Abstract excerpt
KISS1 is a broadly functional secreted proprotein that is then processed into small peptides, termed kisspeptins (KP). Since sequence analysis showed cleavage at KR or RR dibasic sites of the nascent protein, it was hypothesized that enzyme(s) belonging to the proprotein convertase family of proteases process KISS1 to generate KP. To this end, cell lines over-expressing KISS1 were treated with the proprotein...
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