Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Variants of the carboxyl-terminal KDEL sequence direct intracellular retention.

The Journal of biological chemistry - 15 Apr 1990

Andres D A, Dickerson I M, Dixon J E

Abstract excerpt

Soluble proteins which reside in the lumen of the endoplasmic reticulum share a common carboxyl-terminal tetrapeptide Lys-Asp-Glu-Leu (KDEL). Addition of the tetrapeptide to a normally secreted protein is both necessary and sufficient to cause retention in the endoplasmic reticulum. In order to characterize the critical residues in the KDEL signal, cDNAs encoding proneuropeptide Y (pro-NPY) with the 4-amino acid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Cell Line
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Vectors

Share to Molecular Sequence Data

Share to Plasmids

Share to Restriction Mapping

Share to Sequence Homology, Nucleic Acid

Source

Identifiers

PMID: 2318841

Genes

NPY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variants of the carboxyl-terminal KDEL sequence direct intracellular retention.PMID 2318841Read ↗

Biosynthesis and posttranslational processing of site-directed endoproteolytic cleavage mutants of pro-neuropeptide Y in mouse pituitary cells.Semantic proximity Read ↗

Cell-type specific posttranslational processing of peptides by different pituitary cell lines.Semantic proximity Read ↗

A diabetes insipidus vasopressin prohormone altered outside the central core of neurophysin accumulates in the endoplasmic reticulum.Semantic proximity Read ↗

Intracellular targeting of truncated secretory peptides in the mammalian heart and brain.Semantic proximity Read ↗

Expression of mutant ELH prohormones in AtT-20 cells: the relationship between prohormone processing and sorting.Semantic proximity Read ↗

Prohormone-convertase 1 processing enhances post-Golgi sorting of prothyrotropin-releasing hormone-derived peptides.Semantic proximity Read ↗

Disruption of disulfide bond formation alters the trafficking of prothyrotropin releasing hormone (proTRH)-derived peptides.Semantic proximity Read ↗

Endoplasmic reticulum protein targeting of phospholamban: a common role for an N-terminal di-arginine motif in ER retention?Semantic proximity Read ↗

An extended tyrosine-targeting motif for endocytosis and recycling of the dense-core vesicle membrane protein phogrin.Semantic proximity Read ↗

Localization of the signal for rapid internalization of the bovine cation-independent mannose 6-phosphate/insulin-like growth factor-II receptor to amino acids 24-29 of the cytoplasmic tail.Semantic proximity Read ↗

Peptide hormone precursor processing: getting sorted?Semantic proximity Read ↗

Impaired trafficking of mutated AVP prohormone in cells expressing rare disease genes causing autosomal dominant familial neurohypophyseal diabetes insipidus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.