Article
Variants of the carboxyl-terminal KDEL sequence direct intracellular retention.
The Journal of biological chemistry - 15 Apr 1990
Andres D A, Dickerson I M, Dixon J E
Abstract excerpt
Soluble proteins which reside in the lumen of the endoplasmic reticulum share a common carboxyl-terminal tetrapeptide Lys-Asp-Glu-Leu (KDEL). Addition of the tetrapeptide to a normally secreted protein is both necessary and sufficient to cause retention in the endoplasmic reticulum. In order to c...
Topics
- Amino Acid Sequence
- Animals
- Cell Line
- Genetic Variation
- Genetic Vectors
- Molecular Sequence Data
- Neuropeptide Y
- Peptide Fragments
- Peptide Mapping
- Plasmids
- Pro-Opiomelanocortin
- Protein Precursors