Article
Cleavage of a hydrophilic C-terminal domain increases growth-inhibitory activity of oncostatin M.
Molecular and cellular biology - 1 May 1990
Linsley P S, Kallestad J, Ochs V, Neubauer M
Abstract excerpt
Oncostatin M is a polypeptide cytokine, produced by normal and malignant hematopoietic cells, that has several in vitro activities, including the ability to inhibit growth of cultured carcinoma cells. Here we present a structural and functional comparison of two oncostatin M-related proteins (Mr...
Topics
- Amino Acid Sequence
- Cells, Cultured
- DNA Mutational Analysis
- Glycosylation
- Growth Inhibitors
- In Vitro Techniques
- Molecular Sequence Data
- Molecular Weight
- Mutation
- Oncostatin M
- Peptides
- Protein Processing, Post-Translational
- Structure-Activity Relationship