Article
Involvement of a polyproline helix-like structure in the interaction of 7B2 with prohormone convertase 2.
The Journal of biological chemistry - 20 Sept 1996
Zhu X, Lamango N S, Lindberg I
Abstract excerpt
The neuroendocrine protein 7B2 is known to be involved in the biosynthesis and activity of prohormone convertase 2 (PC2). Previous studies have demonstrated that while the carboxyl-terminal portion of 7B2 (residues 155-186) regulates the enzymatic activity of PC2, the amino terminus of the molecu...
Topics
- Animals
- CHO Cells
- Cricetinae
- Enzyme Activation
- Enzyme Stability
- Mutation
- Nerve Tissue Proteins
- Neuroendocrine Secretory Protein 7B2
- Peptides
- Pituitary Hormones
- Proline
- Proprotein Convertase 2
- Protein Binding
- Protein Denaturation
- Protein Precursors
- Protein Processing, Post-Translational
- Protein Structure, Secondary
- Structure-Activity Relationship