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Article

Development of protein-based inhibitors of the proprotein of convertase SKI-1/S1P: processing of SREBP-2, ATF6, and a viral glycoprotein.

The Journal of biological chemistry - 23 Apr 2004

Pullikotil Philomena, Vincent Martin, Nichol Stuart T, Seidah Nabil G

Abstract excerpt

Processing of membrane-bound transcription factors such as sterol regulatory element-binding proteins (SREBPs) and the ER-stress response factor ATF6, and glycoproteins of some hemorrhagic fever viruses are initiated by the proprotein convertase SKI-1/S1P. So far, no cellular protein-based inhibi...

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Share to Activating Transcription Factor 6
Share to alpha 1-Antitrypsin
Share to Hemorrhagic Fever Virus, Crimean-Congo

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14970232
DOI: 10.1074/jbc.M313764200

Genes

SKI
ATF6
SDS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14970232-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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