Article
Linkage and association with the NOS2A locus on chromosome 17q11 in multiple sclerosis.
Annals of neurology - 1 Jun 2004
Barcellos Lisa F, Begovich Ann B, Reynolds Rebecca L, Caillier Stacy J, Brassat David, Schmidt Silke, Grams Sarah E, Walker Karen, Steiner Lori L, Cree Bruce A C, Stillman Althea, Lincoln Robin R, Pericak-Vance Margaret A, Haines Jonathan L, Erlich Henry A, Hauser Stephen L, Oksenberg Jorge R
Abstract excerpt
A large body of research supports a multifactorial cause in multiple sclerosis (MS), with an underlying genetic susceptibility likely acting in concert with undefined environmental exposures. Here, we used a highly efficient multilocus genotyping assay to study single nucleotide polymorphisms representing variation in 34 genes from inflammatory pathways in a well-characterized MS familial data set. Evidence of...
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