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Article

Multifactor dimensionality reduction reveals gene-gene interactions associated with multiple sclerosis susceptibility in African Americans.

Genes and immunity - 1 Jun 2006

Brassat D, Motsinger A A, Caillier S J, Erlich H A, Walker K, Steiner L L, Cree B A C, Barcellos L F, Pericak-Vance M A, Schmidt S, Gregory S, Hauser S L, Haines J L, Oksenberg J R, Ritchie M D

Abstract excerpt

Multiple sclerosis (MS) is a common disease of the central nervous system characterized by inflammation, myelin loss, gliosis, varying degrees of axonal pathology, and progressive neurological dysfunction. Multiple sclerosis exhibits many of the characteristics that distinguish complex genetic disorders including polygenic inheritance and environmental exposure risks. Here, we used a highly efficient multilocus...

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Identifiers

PMID: 16625214
DOI: 10.1038/sj.gene.6364299
PMCID: PMC4339061

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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