Article
An investigation of NOS2A promoter polymorphisms in Australian multiple sclerosis patients.
European journal of human genetics : EJHG - 1 Jul 2005
Bugeja Matthew J, Booth David R, Bennetts Bruce H, Heard Robert N S, Burgner David, Stewart Graeme J
Abstract excerpt
As with other major autoimmune diseases, susceptibility to multiple sclerosis (MS) is believed to result from the complex interaction of a number of genes, each with modest effect. Extensive research of experimental autoimmune encephalomyelitis in mice and several direct MS studies have implicated NOS2A, which encodes the inducible form of nitric oxide synthase, and the genetic region encoding NOS2A, 17q11.2, has...
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