Article
Large-scale studies of the HphI insulin gene variable-number-of-tandem-repeats polymorphism in relation to Type 2 diabetes mellitus and insulin release.
Diabetologia - 1 Jun 2004
Hansen S K, Gjesing A P, Rasmussen S K, Glümer C, Urhammer S A, Andersen G, Rose C S, Drivsholm T, Torekov S K, Jensen D P, Ekstrøm C T, Borch-Johnsen K, Jørgensen T, McCarthy M I, Hansen T, Pedersen O
Abstract excerpt
AIMS/HYPOTHESIS: The class III allele of the variable-number-of-tandem-repeats polymorphism located 5' of the insulin gene (INS-VNTR) has been associated with Type 2 diabetes and altered birthweight. It has also been suggested, although inconsistently, that the class III allele plays a role in glucose-induced insulin response among NGT individuals. METHODS: We investigated the impact of the class III allele on...
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