Article
Heterogeneity of class I INS VNTR allele association with insulin secretion in obese children.
Physiological genomics - 16 May 2006
Le Fur Sophie, Auffray Cédric, Letourneur Franck, Cruaud Corinne, Le Stunff Catherine, Bougnères Pierre
Abstract excerpt
On the basis of the near-complete linkage disequilibrium of the insulin variable number of tandem repeats (INS VNTR) allele with the neighboring -23Hph1 A/T single-nucleotide polymorphism, previous studies have documented the association of class I ("short") and class III ("long") INS VNTR alleles with metabolic parameters, including circulating insulin levels. Using a new method to sequence class I alleles, we...
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