Article
Lack of support for a role of the insulin gene variable number of tandem repeats minisatellite (INS-VNTR) locus in fetal growth or type 2 diabetes-related intermediate traits in United Kingdom populations.
The Journal of clinical endocrinology and metabolism - 1 Jan 2004
Mitchell Simon M S, Hattersley Andrew T, Knight Beatrice, Turner Tina, Metcalf Bradley S, Voss Linda D, Davies David, McCarthy Anne, Wilkin Terence J, Smith George Davey, Ben-Shlomo Yoav, Frayling Timothy M
Abstract excerpt
The insulin gene variable number of tandem repeats minisatellite (INS-VNTR) class III allele is associated with altered fetal growth, type 2 diabetes risk (especially when paternally inherited), and insulin and IGF2 gene expression. Further studies are needed to establish the role of the INS-VNTR in fetal growth and assess whether its effects depend on the parent of origin. We analyzed the INS-VNTR-linked -23...
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