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Article

The insulin gene VNTR is associated with fasting insulin levels and development of juvenile obesity.

Nature genetics - 1 Dec 2000

Le Stunff C, Fallin D, Schork N J, Bougnères P

Abstract excerpt

In millions of people, obesity leads to type 2 diabetes (T2D; also known as non-insulin-dependent diabetes mellitus). During the early stages of juvenile obesity, the increase of insulin secretion in proportion to accumulated fat balances insulin resistance and protects patients from hyperglycaemia. After several decades, however,beta-cell function deteriorates and T2D develops in approximately 20% of obese...

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Source

Identifiers

PMID: 11101842
DOI: 10.1038/82579

Genes

INS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The insulin gene VNTR is associated with fasting insulin levels and development of juvenile obesity.PMID 11101842Read ↗

Insulin gene variable number of tandem repeats (INS VNTR) genotype and metabolic syndrome in childhood obesity.Semantic proximity Read ↗

Association of Kir6.2 and INS VNTR variants with glucose homeostasis in young obese.Semantic proximity Read ↗

Insulin gene variable number of tandem repeats is associated with increased fat mass during adolescence in non-obese girls.Semantic proximity Read ↗

Heterogeneity of class I INS VNTR allele association with insulin secretion in obese children.Semantic proximity Read ↗

INS VNTR is a QTL for the insulin response to oral glucose in obese children.Semantic proximity Read ↗

VNTR polymorphism of the insulin gene and childhood overweight in a general population.Semantic proximity Read ↗

Common variants in the regulatory region of the insulin gene are associated with fasting plasma insulin levels in juvenile obesity.Semantic proximity Read ↗

The <i>TH01</i> microsatellite and <i>INS</i> VNTR are strongly associated with type 2 diabetes and fasting insulin secretionSemantic proximity Read ↗

Insulin gene mutations and posttranslational and translocation defects: associations with diabetes.Semantic proximity Read ↗

Insulin gene VNTR genotype is associated with insulin sensitivity and secretion in infancy.Semantic proximity Read ↗

Paternal transmission of the very common class I INS VNTR alleles predisposes to childhood obesity.Semantic proximity Read ↗

The insulin gene in diabetes.Semantic proximity Read ↗

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