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Article

Assembly of a fragmented ribonucleotide reductase by protein interaction domains derived from a mobile genetic element.

Nucleic acids research - 1 Mar 2011

Crona Mikael, Moffatt Connor, Friedrich Nancy C, Hofer Anders, Sjöberg Britt-Marie, Edgell David R

Abstract excerpt

Ribonucleotide reductase (RNR) is a critical enzyme of nucleotide metabolism, synthesizing precursors for DNA replication and repair. In prokaryotic genomes, RNR genes are commonly targeted by mobile genetic elements, including free standing and intron-encoded homing endonucleases and inteins. Here, we describe a unique molecular solution to assemble a functional product from the RNR large subunit gene, nrdA that...

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Identifiers

PMID: 20972217
DOI: 10.1093/nar/gkq924
PMCID: PMC3045599

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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