Article
A new method to characterize hydrophobic organization of proteins: application to rational protein engineering of barnase.
Journal of biomolecular structure & dynamics - 1 Feb 1998
Golovanov A P, Efremov R G, Jaravine V A, Vergoten G, Kirpichnikov M P, Arseniev A S
Abstract excerpt
We present a new algorithm for characterization of protein spatial structure basing on the molecular hydrophobicity potential approach. The method is illustrated by the analysis of three-dimensional structure of barnase and barnase-barstar complex. Current approach enables identification of amino...
Topics
- Algorithms
- Amino Acid Sequence
- Amino Acids
- Bacterial Proteins
- Enzyme Stability
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Protein Conformation
- Protein Engineering
- Ribonucleases
- Software