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Article

The ubiquitin-conjugating DNA repair enzyme HR6A is a maternal factor essential for early embryonic development in mice.

Molecular and cellular biology - 1 Jun 2004

Roest Henk P, Baarends Willy M, de Wit Jan, van Klaveren Jan W, Wassenaar Evelyne, Hoogerbrugge Jos W, van Cappellen Wiggert A, Hoeijmakers Jan H J, Grootegoed J Anton

Abstract excerpt

The Saccharomyces cerevisiae RAD6 protein is required for a surprising diversity of cellular processes, including sporulation and replicational damage bypass of DNA lesions. In mammals, two RAD6-related genes, HR6A and HR6B, encode highly homologous proteins. Here, we describe the phenotype of cells and mice deficient for the mHR6A gene. Just like mHR6B knockout mouse embryonic fibroblasts, mHR6A-deficient cells...

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Identifiers

PMID: 15169909
DOI: 10.1128/MCB.24.12.5485-5495.2004
PMCID: PMC419895

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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