Article
Inactivation of the HR6B ubiquitin-conjugating DNA repair enzyme in mice causes male sterility associated with chromatin modification.
Cell - 6 Sept 1996
Roest H P, van Klaveren J, de Wit J, van Gurp C G, Koken M H, Vermey M, van Roijen J H, Hoogerbrugge J W, Vreeburg J T, Baarends W M, Bootsma D, Grootegoed J A, Hoeijmakers J H
Abstract excerpt
The ubiquitin-conjugating yeast enzyme RAD6 and its human homologs hHR6A and hHR6B are implicated in postreplication repair and damage-induced mutagenesis. The yeast protein is also required for sporulation and may modulate chromatin structure via histone ubiquitination. We report the phenotype of the first animal mutant in the ubiquitin pathway: inactivation of the hHR6B-homologous gene in mice causes male...
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