Article
Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages.
Experimental cell research - 15 Nov 2006
Liebe B, Petukhova G, Barchi M, Bellani M, Braselmann H, Nakano T, Pandita T K, Jasin M, Fornace A, Meistrich M L, Baarends W M, Schimenti J, de Lange T, Keeney S, Camerini-Otero R D, Scherthan H
Abstract excerpt
Meiosis pairs and segregates homologous chromosomes and thereby forms haploid germ cells to compensate the genome doubling at fertilization. Homologue pairing in many eukaryotic species depends on formation of DNA double strand breaks (DSBs) during early prophase I when telomeres begin to cluster at the nuclear periphery (bouquet stage). By fluorescence in situ hybridization criteria, we observe that...
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