Article
Loss of HR6B ubiquitin-conjugating activity results in damaged synaptonemal complex structure and increased crossing-over frequency during the male meiotic prophase.
Molecular and cellular biology - 1 Feb 2003
Baarends Willy M, Wassenaar Evelyne, Hoogerbrugge Jos W, van Cappellen Gert, Roest Henk P, Vreeburg Jan, Ooms Marja, Hoeijmakers Jan H J, Grootegoed J Anton
Abstract excerpt
The ubiquitin-conjugating enzymes HR6A and HR6B are the two mammalian homologs of Saccharomyces cerevisiae RAD6. In yeast, RAD6 plays an important role in postreplication DNA repair and in sporulation. HR6B knockout mice are viable, but spermatogenesis is markedly affected during postmeiotic steps, leading to male infertility. In the present study, increased apoptosis of HR6B knockout primary spermatocytes was...
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