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Article

A feedback loop in the polo-like kinase activation pathway.

The Journal of biological chemistry - 30 Jul 2004

Erikson Eleanor, Haystead Timothy A J, Qian Yue-Wei, Maller James L

Abstract excerpt

The Xenopus polo-like kinase Plx1 plays important roles during entry into and exit from mitosis (M phase). Previous studies revealed that Plx1 is activated by phosphorylation on serine and threonine residues, and purification of an activating enzyme from mitotic Xenopus egg extracts led to cloning and characterization of Xenopus polo-like kinase kinase (xPlkk1), which can phosphorylate and activate Plx1 in vitro....

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Source

Identifiers

PMID: 15166215
DOI: 10.1074/jbc.M403840200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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