Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The polo-like kinase Plx1 is required for M phase exit and destruction of mitotic regulators in Xenopus egg extracts.

The EMBO journal - 2 Mar 1998

Descombes P, Nigg E A

Abstract excerpt

Polo-like kinases (Plks), named after the Drosophila gene product polo, have been implicated in the regulation of multiple aspects of mitotic progression, including the activation of the Cdc25 phosphatase, bipolar spindle formation and cytokinesis. Genetic analyses performed in yeast and Drosophila suggest a function for Plks at late stages of mitosis, but biochemical data to support such a function in vertebrate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium
Share to Cell Cycle Proteins
Share to Drosophila Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ligases

Share to Mitosis

Share to Mutation

Share to Protein Serine-Threonine Kinases

Share to Recombinant Fusion Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 9482730
DOI: 10.1093/emboj/17.5.1328
PMCID: PMC1170481

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The polo-like kinase Plx1 is required for M phase exit and destruction of mitotic regulators in Xenopus egg extracts.PMID 9482730Read ↗

Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase.Semantic proximity Read ↗

Multiple Requirements of PLK1 during Mouse Oocyte MaturationSemantic proximity Read ↗

A feedback loop in the polo-like kinase activation pathway.Semantic proximity Read ↗

Roles of Pdk1p, a fission yeast protein related to phosphoinositide-dependent protein kinase, in the regulation of mitosis and cytokinesis.Semantic proximity Read ↗

The Drosophila POLO kinase localises to multiple compartments of the mitotic apparatus and is required for the phosphorylation of MPM2 reactive epitopes.Semantic proximity Read ↗

Polo-like kinase 1 is essential for the first mitotic division in the mouse embryoSemantic proximity Read ↗

Uncoupling anaphase-promoting complex/cyclosome activity from spindle assembly checkpoint control by deregulating polo-like kinase 1.Semantic proximity Read ↗

Association of polo-like kinase with α-, β- and γ-tubulins in a stable complexSemantic proximity Read ↗

Polo-like kinase-activating kinasesSemantic proximity Read ↗

Fine tuning the cell cycle: activation of the Cdk1 inhibitory phosphorylation pathway during mitotic exit.Semantic proximity Read ↗

Polo kinase and progression through M phase in Drosophila: a perspective from the spindle poles.Semantic proximity Read ↗

Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.