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The decision to enter mitosis: feedback and redundancy in the mitotic entry network

13 Apr 2009

Abstract excerpt

The decision to enter mitosis is mediated by a network of proteins that regulate activation of the cyclin B-Cdk1 complex. Within this network, several positive feedback loops can amplify cyclin B-Cdk1 activation to ensure complete commitment to a mitotic state once the decision to enter mitosis has been made. However, evidence is accumulating that several components of the feedback loops are redundant for cyclin...

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PMID: 19364923
DOI: 10.1083/jcb.200812045

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