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Article

Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase.

Nature - 8 Mar 2001

Toyoshima-Morimoto F, Taniguchi E, Shinya N, Iwamatsu A, Nishida E

Abstract excerpt

In vertebrate cells, the nuclear entry of Cdc2-cyclin B1 (MPF) during prophase is thought to be essential for the induction and coordination of M-phase events. Phosphorylation of cyclin B1 is central to its nuclear translocation, but the kinases that are responsible remain unknown. Here we have purified a protein kinase from Xenopus M-phase extracts that phosphorylates a crucial serine residue (S147) in the...

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Identifiers

PMID: 11242082
DOI: 10.1038/35065617

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase.PMID 11242082Read ↗

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