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Article

The balance of Polo-like kinase 1 in tumorigenesis

1 Jan 2009

Abstract excerpt

Polo-like kinase 1 (Plk1) belongs to a family of conserved serine/threonine kinases with a polo-box domain, which have similar but non-overlapping functions in the cell cycle progression. Plk1 plays a key role to ensure the normal mitosis. Interestingly, overexpression of Plk1 is associated with tumor development and could serve as a prognostic marker for many cancers. Due to Plk1 overexpression, several Plk1...

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PMID: 19161615
DOI: 10.1186/1747-1028-4-4

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