Article
The Mitotic Cancer Target Polo-Like Kinase 1: Oncogene or Tumor Suppressor?
11 Mar 2019
Abstract excerpt
The master mitotic regulator, Polo-like kinase 1 (Plk1), is an essential gene for the correct execution of cell division. Plk1 has strong clinical relevance, as it is considered a bona fide cancer target, it is found overexpressed in a large collection of different cancer types and this tumoral overexpression often correlates with poor patient prognosis. All these data led the scientific community to historically...