Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Uncoupling anaphase-promoting complex/cyclosome activity from spindle assembly checkpoint control by deregulating polo-like kinase 1.

Molecular and cellular biology - 1 Mar 2005

van de Weerdt Barbara C M, van Vugt Marcel A T M, Lindon Catherine, Kauw Jos J W, Rozendaal Marieke J, Klompmaker Rob, Wolthuis Rob M F, Medema René H

Abstract excerpt

Polo-like kinase 1 (Plk1) plays a role in numerous events in mitosis, but how the multiple functions of Plk1 are separated is poorly understood. We studied regulation of Plk1 through two putative phosphorylation residues, Ser-137 and Thr-210. Using phospho-specific antibodies, we found that Thr-2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anaphase-Promoting Complex-Cyclosome
Share to Mitosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polo-Like Kinase 1

Share to Protein Processing, Post-Translational

Share to Serine

Share to Spindle Apparatus

Share to Threonine

Share to Ubiquitin-Protein Ligase Complexes

Source

Open in PubMed Open full text

Identifiers

PMID: 15713655
DOI: 10.1128/MCB.25.5.2031-2044.2005
PMCID: PMC549351

Genes

APC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15713655-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Uncoupling anaphase-promoting complex/cyclosome activity from spindle assembly checkpoint control by deregulating polo-like kinase 1.PMID 15713655Read ↗

Phosphorylation of threonine 210 and the role of serine 137 in the regulation of mammalian polo-like kinase.Semantic proximity Read ↗

Polo-like kinase 1 phosphorylation of p150Glued facilitates nuclear envelope breakdown during prophase.Semantic proximity Read ↗

Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function.Semantic proximity Read ↗

Polo-like kinases and DNA damage checkpoint: beyond the traditional mitotic functionsSemantic proximity Read ↗

Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase.Semantic proximity Read ↗

Multiple Requirements of PLK1 during Mouse Oocyte MaturationSemantic proximity Read ↗

Molecular interactions of Polo-like-kinase 1 with the mitotic kinesin-like protein CHO1/MKLP-1.Semantic proximity Read ↗

Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1.Semantic proximity Read ↗

The Mitotic Cancer Target Polo-Like Kinase 1: Oncogene or Tumor Suppressor?Semantic proximity Read ↗

Polo box domain of Plk3 functions as a centrosome localization signal, overexpression of which causes mitotic arrest, cytokinesis defects, and apoptosis.Semantic proximity Read ↗

TOPBP1-PLK1 interaction preserves genome integrity during mitosis.Semantic proximity Read ↗

Independent modulation of the kinase and polo-box activities of Cdc5 protein unravels unique roles in the maintenance of genome stability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.