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An updated AL-Base reveals ranked enrichment of immunoglobulin light chain variable genes in AL amyloidosis

2024-09-15

Abstract excerpt

<h4>Background</h4> Each monoclonal antibody light chain associated with AL amyloidosis has a unique sequence. Defining how these sequences lead to amyloid deposition could facilitate faster diagnosis and lead to new treatments. <h4>Methods</h4> Light chain sequences are collected in the Boston University AL-Base repository. Monoclonal sequences from AL amyloidosis, multiple myeloma and the healthy polyclonal im...

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Literature Corpus work
d7643be6-a153-546f-a624-f9ec62f12042
DOI
10.1101/2024.09.11.612490
Open publication

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An updated AL-Base reveals ranked enrichment of immunoglobulin light chain variable genes in AL amyloidosisDOI 10.1101/2024.09.11.612490
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