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Article

An updated AL-base reveals ranked enrichment of immunoglobulin light chain variable genes in AL amyloidosis.

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis - 1 Jun 2025

Morgan Gareth J, Nau Allison N, Wong Sherry, Spencer Brian H, Shen Yun, Hua Axin, Bullard Matthew J, Sanchorawala Vaishali, Prokaeva Tatiana

Abstract excerpt

BACKGROUND: Each monoclonal antibody light chain associated with AL amyloidosis has a unique sequence. Defining how these sequences drive amyloid deposition could facilitate faster diagnosis and lead to new treatments. METHODS: Light chain sequences are collected in the AL-Base repository. Monoclonal sequences from AL amyloidosis, multiple myeloma and the healthy polyclonal immune repertoire were compared to...

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Identifiers

PMID: 39641756
DOI: 10.1080/13506129.2024.2434899
PMCID: PMC12068999

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