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Article

Evidence that amyloidogenic light chains undergo antigen-driven selection.

Blood - 15 Apr 1998

Perfetti V, Ubbiali P, Vignarelli M C, Diegoli M, Fasani R, Stoppini M, Lisa A, Mangione P, Obici L, Arbustini E, Merlini G

Abstract excerpt

AL amyloidosis is characterized by fibrillar tissue deposits (amyloid) composed of monoclonal light chains secreted by small numbers of indolent bone marrow plasma cells whose ontogenesis is unknown. To address this issue and to provide insights into the processes that accompanied pathogenic light chain formation, we isolated the complete variable (V) regions of 14 light (VL) and 3 heavy (VH) chains secreted by...

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PMID: 9531605

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Evidence that amyloidogenic light chains undergo antigen-driven selection.PMID 9531605Read ↗

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An updated AL-Base reveals ranked enrichment of immunoglobulin light chain variable genes in AL amyloidosisSemantic proximity Read ↗

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Identification of clonal immunoglobulin λ light-chain gene rearrangements in AL amyloidosis using next-generation sequencingSemantic proximity Read ↗

Diversity and diversification of light chains in myeloma: the specter of amyloidogenesis by proxy.Semantic proximity Read ↗

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