Article
Comparison of IGLV2-14 light chain sequences of patients with AL amyloidosis or multiple myeloma.
The FEBS journal - 1 Sept 2023
Berghaus Natalie, Schreiner Sarah, Poos Alexandra M, Raab Marc S, Goldschmidt Hartmut, Mai Elias K, Salwender Hans-Jürgen, Bernhard Helga, Thurner Lorenz, Müller-Tidow Carsten, Weinhold Niels, Hegenbart Ute, Schönland Stefan O, Huhn Stefanie
Abstract excerpt
Light chain amyloidosis (AL) is one of the most common forms of systemic amyloidosis and is caused by the deposition of insoluble fibrils derived from misfolded and aggregated immunoglobulin light chains (LC). To uncover the causes leading to this aggregation, we compared AL LC sequences with those of patients with the related disease multiple myeloma (MM), which do not aggregate in insoluble fibrils in vivo....
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